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High dose of maternal folic acid supplementation is associated to infant asthma

Yang, Liu, Jiang, Liwen, Bi, Meirong, Jia, Xiaodong, Wang, Youqing, He, Chuan, Yao, Yao, Wang, Jun, Wang, Zhiping
Food and chemical toxicology 2015 v.75 pp. 88-93
asthma, case-control studies, folic acid, infants, meta-analysis, neural tube defects, patients, pregnancy, quantitative analysis, risk, risk reduction, toxicology
Maternal folic acid supplementation had a positive effect on preventing neural tube defects (NTDs), but its effects in infant asthma remained unclear. A hospital-based case–control study was conducted with outpatients between March 2010 and March 2011 including 150 onset infant asthma cases and 212 controls, together with a meta-analysis involving 14 438 participants, was performed. The association between maternal folic acid supplementation and the risk of infant asthma was not significant either in the meta-analysis (OR = 1.06, 95% CI = 0.99–1.14) or in the case–control study (OR = 0.72, 95% CI = 0.37–1.39). However, quantitative analysis of the supplementation dose demonstrated that the risk of infant asthma significantly increased for the infants whose mother were with high-dose supplementation (>72 000 µg•d; OR = 3.16, 95% CI = 1.15–8.71) after adjusting for confounding factors in the case–control study. Meanwhile, the risk of infant asthma significantly decreased for the infants whose mother were with low-dose supplementation (<36 000 µg•d; OR = 0.36, 95% CI = 0.17–0.77). A high dose of folic acid supplementation for mother during pregnancy was associated with an increased risk of infant asthma, whereas supplementation with a relatively low-dose was associated with a decreased risk of infant asthma. These findings should be further investigated in a large population.