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In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Author:
Escrivá, L., Font, G., Manyes, L.
Source:
Food and chemical toxicology 2015 v.78 pp. 185-206
ISSN:
0278-6915
Subject:
Fusarium, T-2 toxin, acute toxicity, chickens, deoxynivalenol, feed contamination, fumonisin B1, in vivo studies, intravenous injection, mice, nivalenol, oral administration, rats, subacute toxicity, subchronic toxicity, swine, teratogenicity, toxicity testing, zearalenone
Abstract:
This review summarizes the information regarding the in vivo studies of Fusarium mycotoxins in the last decade. The most common studies are classified as subacute toxicity, subchronic toxicity, acute toxicity, toxicokinetic studies and teratogenicity in order of importance. The most used animals in in vivo studies are pigs, rats, chickens and mice. Fumonisin B1, deoxynivalenol, zearalenone, nivalenol and T-2 toxin are the most studied fusarotoxins. Studies with combinations of mycotoxins are also frequent, deoxynivalenol generally being one of them. The predominant route of administration is oral, administered mostly in the form of naturally contaminated feed. Other administration routes also used are intraperitoneal, intravenous and subcutaneous. In vivo research on Fusarium mycotoxins has increased since 2010 highlighting the need for such studies in the field of food and feed safety.
Agid:
5419622