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RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

Author:
Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., Sipes, I.G., Wall, B., Wilcox, D.K.
Source:
Food and chemical toxicology 2015 v.84 pp. S100
ISSN:
0278-6915
Subject:
absorption, breathing, developmental toxicity, genotoxicity, ingredients, no observed adverse effect level, odors, phototoxicity, rats, reproductive toxicology, safety assessment, subchronic toxicity
Abstract:
The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.
Agid:
5419785