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The pecan nut (Carya illinoinensis) and its oil and polyphenolic fractions differentially modulate lipid metabolism and the antioxidant enzyme activities in rats fed high-fat diets

Author:
Domínguez-Avila, Jesús A., Alvarez-Parrilla, Emilio, López-Díaz, José A., Maldonado-Mendoza, Ignacio E., Gómez-García, María del Consuelo, de la Rosa, Laura A.
Source:
Food chemistry 2015 v.168 pp. 529-537
ISSN:
0308-8146
Subject:
Carya illinoinensis, apolipoprotein B, bioactive properties, blood lipids, blood serum, catalase, cholesterol, enzyme activity, gene expression regulation, glutathione peroxidase, glutathione transferase, high fat diet, leptin, lipid metabolism, lipid peroxidation, liver, low density lipoprotein, males, messenger RNA, oils, oxidative stress, pecans, polyphenols, rats, triacylglycerols
Abstract:
Tree nuts such as pecans (Carya illinoinensis) contain mostly oil but are also a source of polyphenols. Nut consumption has been linked to a reduction in serum lipid levels and oxidative stress. These effects have been attributed to the oil while overlooking the potential contribution of the polyphenols. Because the evidence regarding each fraction’s bioactivity is scarce, we administered high-fat (HF) diets to male Wistar rats, supplementing them with pecan oil (HF+PO), pecan polyphenols (HF+PP) or whole pecans (HF+WP), and analysed the effects of each fraction. The HF diet increased the serum leptin and total cholesterol (TC) with respect to the control levels. The HF+WP diet prevented hyperleptinemia and decreased the TC compared with the control. The HF+WP diet upregulated the hepatic expression of apolipoprotein B and LDL receptor mRNAs with respect to the HF levels. The HF+PO diet reduced the level of triacylglycerols compared with the control. The HF+PP diet stimulated the hepatic expression of liver X receptor alpha mRNA. The HF+WP diet increased the activities of hepatic catalase, glutathione peroxidase and glutathione S transferase compared with the control, and decreased the degree of lipid peroxidation compared with the HF diet. The most bioactive diet was the WP diet.
Agid:
5423025