Jump to Main Content
Effects of long-term consumption of standard diets including glucose–lysine model glycated compounds on the antioxidant status of adult rats
- Pastoriza, Silvia, Rufián-Henares, José Ángel, Delgado-Andrade, Cristina
- Food chemistry 2015 v.183 pp. 283-290
- Maillard reaction products, adults, antioxidant activity, antioxidants, blood serum, diet, excretion, glutathione peroxidase, liver, long term effects, melanoidins, muscles, oxidation, rats
- Our purpose was to evaluate the uptake of antioxidant capacity (AC) in rats fed long-term a diet containing commonly consumed Maillard reaction products (MRPs) from the glucose–lysine system. The effects on the oxidative status of liver, biceps brachii muscle and serum were also tested. The presence of model MRPs in the diet, especially melanoidins, led to a significantly higher intake (24.0μmolTrolox/day), faecal excretion (0.604μmolTrolox/day), and uptake (23.4μmolTrolox/day) of AC, although the uptake rate remained stable compared to the control group (97.5%). Consumption of the assayed MRPs did not affect the hepatic antioxidant defence while some positive modifications, like an increase in glutathione peroxidase, were detected in muscle (29%) and serum (400%). This pointed to an improved antioxidant capacity. Despite the interesting findings for these specific MRPs, attention must be paid to the overall consumption of MRPs from different sources in a conventional diet, due to their implications in the development/advance of many disorders.