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Genetics of weight loss: A basis for personalized obesity management

Author:
Martínez, J. Alfredo, Milagro, Fermin I.
Source:
Trends in food science & technology 2015 v.42 no.2 pp. 97-115
ISSN:
0924-2244
Subject:
bioinformatics, interleukin-6, metabolomics, metagenomics, nutrigenomics, obesity, phenotype, single nucleotide polymorphism, systematic review, weight loss
Abstract:
A personalized nutritional approach, based not only on phenotypic traits but also on genetic make-up, may help to control body weight and obesity. Recent advances in nutrigenetics, bioinformatics and genome-wide association/metabolomic/metagenomic studies are set to unleash a revolution in personalized nutrition. This article performs a systematic review of nutrigenetic data concerning single nucleotide polymorphisms (SNPs) involved in weight loss that are considered polygenic. SNPs located in or near FTO, MC4R, MC3R, POMC, LEP, LEPR, PLIN1, APOA5, LIPC, FABP2, INSIG2, IRS1, GIPR, ADBR2, ADRB3, UCP1, RETN, ADIPOQ, IL6, PPARG, TCF7L2, and CLOCK, among others, are comprehensively reviewed.
Agid:
5427707