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Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation

Li, C.C., Lin, Y.T., Chen, Y.T., Sie, S.F., Chen-Yang, Y.W.
Journal of photochemistry and photobiology 2015 v.148 pp. 277-283
Fourier transform infrared spectroscopy, UV filters, differential scanning calorimetry, drug carriers, emulsions, encapsulation, glass, phototoxicity, porous media, silica, skin (animal), sol-gel processing, sunscreens, thermogravimetry, ultraviolet radiation
In this study, various amounts of benzophenone-3 (BP-3), a solid-type of organic UV-filter, were encapsulated in mesoporous silica (MS) to form the BP-3 encapsulated by MS UV-filters (BESs), BES-1 and BES-2, via in-situ sol–gel process. The characterization of BESs was completed using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that of the BES filters, BES-2 containing emulsion (BES-2-E) exhibited about 2times and 1.64times higher SPF and erythemal UV-A PF values, respectively, and after 3months about 7–8times higher protection retention capability than the free BP-3 containing emulsion (BP-3-E). Moreover, the result of the in vitro skin penetration test using Franz glass diffusion cell indicated that the skin permeation of BP-3 from BESs was about 3times lower than from BP-3-E. This property is particularly important for sunscreens because the amount of sunscreen penetration inside the stratum corneum directly correlates to its UV protection ability, and consequently its ability to reduce phototoxic and photo-allergic reactions that are damaging to the skin. The results of this study demonstrated the potential of as-prepared BES-2 as a UV-filter for cosmetic products.