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Enhancement of l-cysteine production by disruption of yciW in Escherichia coli
- Kawano, Yusuke, Ohtsu, Iwao, Takumi, Kazuhiro, Tamakoshi, Ai, Nonaka, Gen, Funahashi, Eri, Ihara, Masaki, Takagi, Hiroshi
- Journal of bioscience and bioengineering 2015 v.119 no.2 pp. 176-179
- Escherichia coli, cysteine, regulon, sulfur, transactivators
- Using in silico analysis, the yciW gene of Escherichia coli was identified as a novel l-cysteine regulon that may be regulated by the transcriptional activator CysB for sulfur metabolic genes. We found that overexpression of yciW conferred tolerance to l-cysteine, but disruption of yciW increased l-cysteine production in E. coli.