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Emergence of novel clade 2.3.4 influenza A (H5N1) virus subgroups in Yunnan Province, China

Hu, Tingsong, Song, Jianling, Zhang, Wendong, Zhao, Huanyun, Duan, Bofang, Liu, Qingliang, Zeng, Wei, Qiu, Wei, Chen, Gang, Zhang, Yingguo, Fan, Quanshui, Zhang, Fuqiang
Infection, genetics, and evolution 2015 v.33 pp. 95-100
Influenza A virus, avian influenza, chickens, eggs, farms, genes, sequence analysis, vaccines, viruses, China
From December 2013 to March 2014, a major wave of highly pathogenic avian influenza outbreak occurred in poultry in Yunnan Province, China. We isolated and characterized eight highly pathogenic avian influenza A (H5N1) viruses from poultry. Full genome influenza sequences and analyses have been performed.Sequence analyses revealed that they belonged to clade 2.3.4 but did not fit within the three defined subclades. The isolated viruses were provisional subclade The provisional subclade viruses with six internal genes from avian influenza A (H5N2) viruses in 2013 were the novel reassortant influenza A (H5N1) viruses which were associated with the outbreak of H5N1 occurred in egg chicken farms in Yunnan Province. The HA genes were similar to subtype H5 viruses isolated from January to March of 2014 in Asia including H5N6 and H5N8. The NA genes were most closely related to A/chicken/Vietnam/NCVD-KA423/2013 (H5N1) from the subclade 2.3.2. The HI assay demonstrated a lack of antigenic relatedness between clades and (RE-5 vaccine strain) or (RE-6 vaccine strain).