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Effect of plant sterols compared with ezetimibe on oxidative stress in patients treated with statins

Bertolami, Adriana, Botelho, Patrícia B., Macedo, Luciene F.L., Abdalla, Dulcinéia S.P., Faludi, André A., Galasso, Melissa, Castro, Inar A.
Journal of functional foods 2014 v.10 pp. 178-186
biomarkers, chocolate, drugs, functional foods, glutathione-disulfide reductase, noninsulin-dependent diabetes mellitus, oxidative stress, patients, phytosterols, sterol esters, superoxide dismutase
This study aimed to compare the action of a drug (ezetimibe) and a functional food containing plant sterol esters on oxidative stress biomarkers. In this double-blind study, 37 type 2 diabetic patients on statin treatment were randomly assigned to receive ezetimibe 10.0 mg/day or to consume a chocolate containing 2.1 g of plant sterol esters for 6 weeks. It was observed that ezetimibe promoted an increase of superoxide dismutase and glutathione reductase activities, while plant sterols did not change these biomarkers. Among individuals who showed the greatest LDL-C and oxLDL-C reduction, the oxLDL-C reduction observed in individuals under plant sterol treatment (−20.0%) did not differ from the values found in individuals treated with ezetimibe (−21.1%). In addition, 16 patients on plant sterol treatment reached the optimal therapeutic goal for LDL-C (<70 mg/dL). Plant sterols added to a non-sugar chocolate bar represent an alternative to statin co-therapy.