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Antiepileptic activity of ellagic acid, a naturally occurring polyphenolic compound, in mice

Dhingra, Dinesh, Jangra, Aabha
Journal of functional foods 2014 v.10 pp. 364-369
brain, diazepam, ellagic acid, gamma-aminobutyric acid, long term effects, males, mice, mortality, seizures
Acute and chronic effects of ellagic acid on pentylenetetrazole and picrotoxin-induced convulsions were evaluated in Swiss young male albino mice. Ellagic acid (20 and 40 mg/kg, p.o.) and diazepam (0.5 mg/kg, i.p.) per se were administered once for acute treatment and 14 successive days for chronic treatment. Pentylenetetrazole (80 mg/kg, i.p.) induced tonic and clonic convulsions, but picrotoxin (6 mg/kg, i.p.) induced only tonic convulsions. Acute administration of higher dose (40 mg/kg) and chronic administration of both the doses of ellagic acid significantly delayed onset of convulsions, decreased duration of clonic and tonic convulsions; and reduced mortality as compared to pentylenetetrazole and picrotoxin treated control. Ellagic acid also reversed pentylenetetrazole and picrotoxin-induced decrease in brain GABA levels. Acute and chronic administration of diazepam showed significant anticonvulsant activity and increased brain GABA levels. Thus, ellagic acid showed significant antiepileptic activity in mice probably through increase of GABAergic transmission in brain.