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Cyclohexene long-chain fatty acid esters from Uvaria dulcis (Dunal)

Author:
Kaweetripob, Wirongrong, Mahidol, Chulabhorn, Prawat, Hunsa, Ruchirawat, Somsak
Source:
Phytochemistry letters 2015 v.12 pp. 248-251
ISSN:
1874-3900
Subject:
Uvaria, benzyl benzoate, branches, cyclohexenes, cytotoxicity, fatty acid esters, long chain fatty acids, lupeol, metabolites, nuclear magnetic resonance spectroscopy
Abstract:
Two new cyclohexene long-chain fatty acid esters, namely Dulcisenes A and B, were isolated from the twigs of the Uvaria dulcis together with seven known compounds, uvarigranol E, (−)-zeylenol, ellipeiopsol B, 5,7-dihydroxyflavone, 8-hydroxy-5,7-dimethoxyflavanone, lupeol, and benzyl benzoate. The structures of the isolated compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D, 2D NMR and HR TOF MS. Several of these metabolites were tested for cytotoxicity against HepG2, A549, S102, HuCCA-1, HeLa, MDA-MB-231, T47D, HL-60, and P388 cell lines.
Agid:
5442997