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Two new spirostanol saponins from the the roots and rhizomes of Tupistra chinensis

Author:
Song, Xiaomei, Li, Yuze, Zhang, Dongdong, Jiang, Yi, Wang, Wei, Song, Bei, Tang, Zhishu, Cui, Jiucheng, Yue, Zhenggang
Source:
Phytochemistry letters 2015 v.13 pp. 6-10
ISSN:
1874-3900
Subject:
cytotoxicity, inhibitory concentration 50, neoplasm cells, physicochemical properties, rhizomes, roots, saponins, spectral analysis
Abstract:
Two new spirostanol saponins (1) and (2), together with three known saponins (3–5), were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as (20S, 22R)-spirost-25(27)-en-1β, 3β, 4β, 5β-tetraol-5-O-β-d-glucopyranoside (1) and (20S, 22R)-spirost-25(27)-en-1β, 3β, 5β-triol-5-O-β-d-glucopyranoside (2), (20S, 22R)-spirost-25(27)-en-1β, 2β, 3β, 4β, 5β-pentaol-5-O-β-d-glucopyranoside (3), Δ25(27)-pentrogenin (4) and ranmogenin A (5) on the basis of physicochemical properties and spectral analysis. The isolated compounds were evaluated for their cytotoxic activities against A549 and H1299 tumor cell lines in vitro. Among them, compound 2 showed cytotoxicities against A549 cells (IC50 52.66±3.12μmolL−1) and H1299 cells (IC50 57.29±2.51μmolL−1), respectively.
Agid:
5443019