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Isoflavones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities
- Li, Lan, Shen, Qin-Peng, Liu, Chun-Bo, Wang, Yun, Yao, Jian-Ju, Zhang, Tao, Zhang, Feng-Mei, He, Pei, Shi, Xiao-Xi, Liu, Zhi-Hua, Miao, Ming-Ming, Yang, Guang-Yu
- Phytochemistry letters 2015 v.13 pp. 156-159
- Nicotiana tabacum, flavones, isoflavones, leaves, nuclear magnetic resonance spectroscopy, spectral analysis, viruses
- Three new isoflavones, 4′,8-dihydroxy-6,7-dimethoxyisoflavone (1), 4′,6-dihydroxy-8-methoxycarbonyl-7-methoxyisoflavone (2), 4′,7-dimethoxy-8-hydroxymethyl-6-hydroxyisoflavone (3), together with three known flavones (4–6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1–3 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1–3 (at the concentration of 20μM) exhibited anti-TMV activities with inhibition rates of 25.2, 22.6, and 27.4%, respectively.