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Canangalias A and B from the stem bark of Cananga latifolia
- Phatchana, Ratchanee, Thongsri, Yordhathai, Somwaeng, Ratree, Piboonpol, Kewalin, Yenjai, Chavi
- Phytochemistry letters 2015 v.13 pp. 147-151
- Cananga, Pythium insidiosum, alkaloids, antifungal properties, bark, fever, juvenile hormones, lignans, phenylpropanoids
- Cananga latifolia, a Thai medical plant, is used for the treatment of dizziness and fever. In this study, two new juvenile hormone III analogues, canangalias A and B (1 and 2) and a new phenylpropanoid derivative, 3-(4′-hydroxy-3′-methoxyphenyl)-1-acetoxy-2-propanol (3) were isolated from the stem bark of this plant. In addition, ten known compounds including three juvenile hormone III analogues (4–6), two alkaloids (7–8), two phenylpropanoids (9–10), a neolignan (11), a lignan (12) and catechaldehyde (13) were found. Compounds 4–7 and 12 exhibited antifungal activity against Pythium insidiosum by showing inhibition zone with diameters of 14.0, 24.0, 16.0, 14.0, and 16.1mm, respectively.