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Canangalias A and B from the stem bark of Cananga latifolia

Author:
Phatchana, Ratchanee, Thongsri, Yordhathai, Somwaeng, Ratree, Piboonpol, Kewalin, Yenjai, Chavi
Source:
Phytochemistry letters 2015 v.13 pp. 147-151
ISSN:
1874-3900
Subject:
Cananga, Pythium insidiosum, alkaloids, antifungal properties, bark, fever, juvenile hormones, lignans, phenylpropanoids
Abstract:
Cananga latifolia, a Thai medical plant, is used for the treatment of dizziness and fever. In this study, two new juvenile hormone III analogues, canangalias A and B (1 and 2) and a new phenylpropanoid derivative, 3-(4′-hydroxy-3′-methoxyphenyl)-1-acetoxy-2-propanol (3) were isolated from the stem bark of this plant. In addition, ten known compounds including three juvenile hormone III analogues (4–6), two alkaloids (7–8), two phenylpropanoids (9–10), a neolignan (11), a lignan (12) and catechaldehyde (13) were found. Compounds 4–7 and 12 exhibited antifungal activity against Pythium insidiosum by showing inhibition zone with diameters of 14.0, 24.0, 16.0, 14.0, and 16.1mm, respectively.
Agid:
5443070