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Aryltetralols from Holostylis reniformis and syntheses of lignan analogous
- Pereira, Marcos D.P., Ferreira, Matheus R., Messiano, Gisele B., Cerávolo, Isabela Penna, Lopes, Lucia M.X., Krettli, Antoniana U.
- Phytochemistry letters 2015 v.13 pp. 200-205
- Aristolochiaceae, Plasmodium falciparum, antimalarials, kidney cells, lignans, mammals, spectral analysis, toxicity
- Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (−)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL50) evaluated. (−)-Cyclogalgravin and (−)-aristoligol exhibited activity (IC50∼10.8 and 8.4μM, respectively), the latter exhibited lower toxicity.