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Two new sesquiterpene coumarins from the seeds of Ferula sinkiangensis

Author:
Li, Guangzhi, Wang, Junchi, Li, Xiaojin, Cao, Li, Lv, Na, Chen, Gang, Zhu, Jun, Si, Jianyong
Source:
Phytochemistry letters 2015 v.13 pp. 123-126
ISSN:
1874-3900
Subject:
Ferula sinkiangensis, coumarins, cytotoxicity, human cell lines, inhibitory concentration 50, neoplasms, seeds, sesquiterpenoids, spectral analysis, stereochemistry
Abstract:
Two new sesquiterpene coumarins, namely, sinkiangenorin F (1) and 8-O-acetyl sinkiangenorin F (2) were isolated from the seeds of Ferula sinkiangensis. The structures of the new compounds, including the relative stereochemistry and the absolute configuration were elucidated through extensive spectroscopic methods. The two compounds were tested against the K562, HeLa, and AGS human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 27.1 and 62.7μM.
Agid:
5443076