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Cytotoxic metabolites from Botryotinia fuckeliana A-S-3: An endophytic fungus from Ajuga decumbens

Author:
Lin, Ting, Wang, Guanghui, Zeng, Dequan, Chen, Haifeng
Source:
Phytochemistry letters 2015 v.13 pp. 206-211
ISSN:
1874-3900
Subject:
Ajuga decumbens, Botrytis cinerea, cytotoxicity, endophytes, fungi, metabolites, sesquiterpenoids, spectral analysis
Abstract:
Available online from an cytotoxic endophytic fungus Botryotinia fuckeliana A-S-3, three cytochalasans phenochalasin B (4), [12]-cytochalasin (5) and one [1,3] dioxacyclotridecino (6), along with two new ent-eudesmane sesquiterpenes, 1-keto-4α,15-epoxyeudesm-11-ol (1), and ent-4(15)-eudesmen-5,6-ol-1-one (2), and one known ent-eudesmane sesquiterpene ent-4(15)-eudesmen-11-ol-1-one (3) were isolated. The structures of these compounds were elucidated by interpretation of spectroscopic data. Among these compounds, two cytotoxic constituents were identified.
Agid:
5443084