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Cytotoxic cytochalasins from the endophytic fungus Eutypella scoparia PSU-H267

Author:
Kongprapan, Thippaya, Rukachaisirikul, Vatcharin, Saithong, Saowanit, Phongpaichit, Souwalak, Poonsuwan, Wimarak, Sakayaroj, Jariya
Source:
Phytochemistry letters 2015 v.13 pp. 171-176
ISSN:
1874-3900
Subject:
Eutypella, Hevea brasiliensis, X-ray diffraction, crystallography, culture media, cytochalasins, cytotoxicity, diterpenoids, endophytes, fungi, inhibitory concentration 50, leaves, neoplasms, spectral analysis
Abstract:
Eleven compounds including one new cytochalasin derivative, scoparasin C (1), four cytochalasins (2–5), four pimarane diterpenes (6–9) and two chromene derivatives (10 and 11) were obtained from a culture broth of Eutypella scoparia PSU-H267 which was isolated from a leaf of Hevea brasiliensis. Their structures were determined by spectroscopic evidence. For compounds 2, 3 and 5, the structures were confirmed by single-crystal X-ray diffraction crystallography. Compounds 1, 3, 4 and 7 were strongly active against Vero cell lines with IC50 values of 1.19, 0.04, 1.01 and 2.50μM, respectively. Only compound 3 displayed potent cytotoxic activity towards KB-oral cavity cancer cell lines with the IC50 value of 2.46μM.
Agid:
5443086