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Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia

Author:
Lia, Zhen-Jie, Wan, Chun-Ping, Cai, Le, Li, Shu-Quan, Zheng, Xi, Qi, Yan, Dong, Jian-Wei, Yin, Tian-Peng, Zhou, Zhi-Xian, Tan, Ning-Hua, Ding, Zhong-Tao
Source:
Phytochemistry letters 2015 v.13 pp. 246-251
ISSN:
1874-3900
Subject:
Pyrus pashia, branches, cisplatin, cytotoxicity, humans, leaves, monoterpenoids, neoplasms, nuclear magnetic resonance spectroscopy, triterpenoids
Abstract:
Twenty terpenoids, including a new triterpenoid (1) and a new monoterpenoid (20), were isolated from the branches and leaves of Pyrus pashia. The structures of two new compounds were determined to be 2α, 3β, 27-trihydroxyolean-12-en-28-oic acid (1) and (4α)-3-(5,5-dimethyltetrahydrofuranyl)-1-buten-3-ol 3-O-β-d-glucopyranoside (20) on the basis of spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and chemical method. Some of the isolated compounds were evaluated for their cytotoxic activity against a panel of human cancer cell lines by MTT assay, using cisplatin as a positive control. Compound 14 exhibited cytotoxic activities against A549 (IC50=19.18±4.26μM), Hela (IC50=12.56±3.89μM), SGC7901 (IC50=10.48±1.95μM) and NHI-1975 (IC50=7.38±2.31μM) cell lines as well as compound 12 displayed cytotoxic activities against A549 (IC50=14.71±1.47μM) and Hela (IC50=12.22±1.88μM) cell lines.
Agid:
5443092