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Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity

Author:
Li, Na, Lee, Hyun-Sun, Zhang, Nan, Sun, Ya-Nan, Li, Jia-Lin, Xing, Shan-Shan, Chen, Jian-Guang, Cui, Long
Source:
Phytochemistry letters 2015 v.13 pp. 286-289
ISSN:
1874-3900
Subject:
Eleutherococcus senticosus, diphenyl ethers, fractionation, in vitro studies, inhibitory concentration 50, spectroscopy
Abstract:
Bioassay-guided fractionation of an EtOAc-soluble extract of Acanthopanax senticosus (Rupr. & Maxim.) Harms yielded two new diphenyl ethers, 3-[3′-methoxy-4′-(4″-formyl-2″,6″-dimethoxy-phenoxy)-phenyl]-propenal (1) and 3-[3′,5′-dihydroxy-4′-(4″-hydroxymethyl-3″,5″-dimethoxy-phenoxy)-phenyl]-propenal (2), along with eight other known compounds (3–10). The structures of these new ethers were elucidated with spectroscopic and physico-chemical analyses. All of the isolates were evaluated for their in vitro inhibitory activity against PTP1B, VHR and PP1. The new compounds (1 and 2) inhibited PTP1B with IC50 values ranging from 9.2±1.4 to 12.6±1.2μM.
Agid:
5443122