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Anti-liver cancer constituents from the thorns of Gleditsia sinensis

Author:
Yu, Jin-Qian, Xian, Yun-Xia, Geng, Yan-Ling, Wang, Dai-Jie, Zhou, Hong-Lei, Wang, Xiao
Source:
Phytochemistry letters 2015 v.13 pp. 343-347
ISSN:
1874-3900
Subject:
Gleditsia sinensis, cytotoxicity, esters, humans, in vitro studies, inhibitory concentration 50, liver neoplasms, nuclear magnetic resonance spectroscopy, plant spines, spectral analysis
Abstract:
Four new long-chain esters of trans-ferulic acid (1–4) were isolated from the thorns of Gleditsia sinensis, together with eight known compounds (5–13). The structure elucidations were achieved by in-depth spectroscopic examination, mainly including multiple 1D- and 2D-NMR and HRESIMS experiments and analyses. Cytotoxic activities of these compounds were evaluated against human liver cancer SK-hep-1 cell line by the MTT in vitro assay. Among them, compound 13 exhibited potent cytotoxic activity with IC50 value of 38.18μM, and compounds 7 and 8 showed moderate cytotoxic activities with IC50 values of 58.11 and 54.61μM, respectively.
Agid:
5443134