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Antibacterially active phenolic lipid derivatives from Comarum salesovianum (Steph.) Aschers. et Gr.

Odontuya, G., Banzragchgarav, O., Murata, T., Batkhuu, J., Sasaki, K., Yoshizaki, F.
Phytochemistry letters 2015 v.13 pp. 360-364
Comarum, Enterococcus faecalis, Gram-positive bacteria, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, aerial parts, antibacterial properties, lipids, methylene chloride, phenol, salicylic acid
The antibacterial activity-guided purification of the dichloromethane fraction of the aerial parts of Comarum salesovianum (Steph.) Gr. led to the isolation and elucidation of three phenolic lipid derivatives: 6-(non-8-enyl) salicylic acid (1), 6-nonyl salicylic acid (2) and 3-(non-8-enyl) phenol (3), which were found for the first time in the natural source. The equal mixture of compounds 1 and 2 exhibited potent inhibitory activity against all tested Gram-positive bacterial strains (Enterococcus faecalis, Micrococcus luteus, Staphylococcus epidermidis and Staphylococcus aureus) with inhibitory zones of 12.2–22.1mm, whereas each single compound showed weaker activity than the mixture of 1 and 2. However, compound 3 strongly inhibited (29.9±1.8) the growth of M. luteus. The presence of salicylic acid with the unsaturated aliphatic side chain is essential for the antibacterial activity strength of phenolic lipid molecules.