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Five new triterpenoid saponins from the Roots of Camellia oleifera C. Abel with cytotoxic activities

Author:
Wu, Jiangping, Zhao, Jianping, Liu, Yanli, Li, Xiaoran, Xu, Qiongming, Feng, Yulin, Khan, Ikhlas A., Yang, Shilin
Source:
Phytochemistry letters 2015 v.13 pp. 379-385
ISSN:
1874-3900
Subject:
Camellia oleifera, adenocarcinoma, breast neoplasms, cytotoxicity, ethanol, humans, neoplasm cells, roots, spectroscopy, sugars, triterpenoid saponins
Abstract:
Five new triterpenoid saponins, oleiferosides P–T (1–5) were isolated from the EtOH extract of the roots of Camellia oleifera C. Abel. The structures of saponins 1–5 were elucidated on the basis of integrated spectroscopic techniques. All the compounds were characterized to be oleanane-type saponins with sugar moieties linked to the C-3 of the aglycone. By using the MTT assay, an in vitro analysis of the cytotoxic activities of these saponins on the human tumor cell lines (lung adenocarcinoma A549 cells, hepatic carcinoma SMMC-7721 cells and breast cancer MCF-7 cells). Among them, compound 4 showed a certain cytotoxic activity against all the tested cell lines.
Agid:
5443150