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Four new sesquiterpenoids as natural nitric oxide (NO) inhibitors from the rhizomes of Curcuma phaeocaulis

Author:
Ma, Jiang-Hao, Zhao, Feng, Wang, Ying, Liu, Yue, Gao, Su-Yu, Ding, Li-Qin, Chen, Li-Xia, Qiu, Feng
Source:
Phytochemistry letters 2015 v.14 pp. 221-225
ISSN:
1874-3900
Subject:
Curcuma, inhibitory concentration 50, macrophages, nitric oxide, rhizomes, sesquiterpenoids, spectroscopy
Abstract:
A new norsesquiterpene named phaeocaulisin N (1), and three new guaiane-type sesquiterpenes named phaeocaulisins O–Q (2–4), together with a known norsesquiterpene (5) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were established based on extensive spectroscopic analysis. Compounds 1 and 5, as far as we know, are the first example of 13-norguaiane-type sesquiterpenes isolated from the genus Curcuma. All of the isolated compounds were tested for inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages. Compound 1 showed strong inhibitory activity on nitric oxide production with IC50 value of 3.58±0.17μM.
Agid:
5443233