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Phage display as a novel promising antivenom therapy: A review

Author:
Roncolato, Eduardo Crosara, Campos, Lucas Benício, Pessenda, Gabriela, Costa e Silva, Luciano, Furtado, Gilvan Pessoa, Barbosa, José Elpidio
Source:
Toxicon 2015 v.93 pp. 79-84
ISSN:
0041-0101
Subject:
animals, antibodies, antivenoms, bacteriophages, neutralization, public health, therapeutics, toxins
Abstract:
In this work, we present recent advances in the use of phage display technology for the preparation of antivenoms for animal toxin neutralization. Even though classical antivenoms have been used since the early 20th century, envenomation remains a global public health problem. Recently, the phage display technique has been used in an attempt to circumvent some of the difficulties associated with traditional preparations of antivenom. Here, we review studies that developed antibody fragments with potential inhibitory effects against animal toxins and discuss the most current technical issues and perspectives regarding phage display technology in this field.
Agid:
5451067