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Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

Author:
Topinka, Jan, Rossner, Pavel, Milcová, Alena, Schmuczerová, Jana, Pěnčíková, Kateřina, Rossnerová, Andrea, Ambrož, Antonín, Štolcpartová, Jitka, Bendl, Jan, Hovorka, Jan, Machala, Miroslav
Source:
Environmental pollution 2015 v.202 pp. 135-145
ISSN:
0269-7491
Subject:
DNA, DNA damage, aerosols, genotoxicity, organic matter, polycyclic aromatic hydrocarbons, temporal variation
Abstract:
This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (dae, μm) coarse (1 < dae < 10), upper- (0.5 < dae < 1) and lower-accumulation (0.17 < dae < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained ∼44% of total c-PAHs, while the ultrafine fraction contained only ∼11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM.
Agid:
5460597