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Blood-brain barrier interfaces and brain tumors

Author:
Lee, Sae-Won, Kim, Woo Jean, Park, Jeong Ae, Choi, Yoon Kyung, Kwon, Yoo-Wook, Kim, Kyu-Won
Source:
Archives of pharmacal research 2006 v.29 no.4 pp. 265-275
ISSN:
0253-6269
Subject:
astrocytes, blood-brain barrier, brain, endothelial cells, growth factors, homeostasis, neoplasms, oxygen
Abstract:
In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.
Agid:
5482865