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Synthesis and cytotoxic activities of 8-alkyl or 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones
- Jung, Jae-Kyung, Jung, Eun-Kyung, Nam-Goong, Kwon, Cho, Jung-Sook, Kim, Hwan-Mook, Park, Sung-Gyu, Yoo, Yeong-Ah, Kwon, Joo-Hee, Lee, Hee-Soon
- Archives of pharmacal research 2006 v.29 no.4 pp. 276
- chemistry, cytotoxicity, humans, neoplasms
- A series of 8-alkyl- and 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for theirin vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).