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Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women

Grygiel-Górniak, Bogna, Mosor, Maria, Marcinkowska, Justyna, Przysławski, Juliusz, Nowak, Jerzy
Journal of biosciences 2016 v.41 no.3 pp. 427-437
alleles, analysis of variance, exons, follicle-stimulating hormone, genetic polymorphism, glucose, haplotypes, linear models, lipid metabolism, obesity, peroxisome proliferator-activated receptors, postmenopause, skinfold thickness, waist circumference, women
The relationship Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms of PPAR gamma-2 with glucose and lipid metabolism is not clear after menopause. We investigated the impact of the Pro12Ala and C1431T silent substitution in the 6th exon in PPAR gamma-2 gene on nutritional and metabolic status in 271 postmenopausal women (122 lean and 149 obese). The general linear model (GLM) approach to the two-way analysis of variance (ANOVA) was used to infer the interactions between the analysed genotypes. The frequency of the Pro-T haplotype was higher in obese than in lean women (p<0.0349). In the analysed GLM models according to obesity status, the C1431C genotype was related to a lower glucose concentration (β=−0.2103) in lean women, and to higher folliculotropic hormone FSH levels (β=0.1985) and lower waist circumferences (β=−0.1511) in obese women. The influence of C1431C was present regardless of the occurrence of the Pro12Ala polymorphism. The co-existence of the C1431C and Pro12Pro genotypes was related to lower values for triceps skinfold thickness compared those for the T1241/X and Ala12/X polymorphisms (β=−0.1425). The presence of C1431C decreased the differences between triceps values that were determined by Pro or Ala allele. In conclusion, C1431T polymorphism seems to have a more essential influence on anthropometric and biochemical parameters than is the case with Pro12Ala polymorphism.