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Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China

Author:
Jin, Tianbo, Shi, Xugang, Wang, Li, Wang, Huijuan, Feng, Tian, Kang, Longli
Source:
BMC genetics 2016 v.17 no.1 pp. 70
ISSN:
1471-2156
Subject:
adults, computer software, databases, drug toxicity, drugs, gene frequency, genetic variation, genome, genotyping, loci, nationalities and ethnic groups, pharmacogenomics, pharmacokinetics, risk, screening, single nucleotide polymorphism, therapeutics, China
Abstract:
BACKGROUND: Within a population, the differences of pharmacogenomic variant frequencies may produce diversities in drug efficacy, safety, and the risk associated with adverse drug reactions. With the development of pharmacogenomics, widespread genetic research on drug metabolism has been conducted on major populations, but less is known about minorities. RESULTS: In this study, we recruited 100 unrelated, healthy Mongol adults from Xinjiang and genotyped 85 VIP variants from the PharmGKB database. We compared our data with eleven populations listed in 1000 genomes project and HapMap database. We used χ² tests to identify significantly different loci between these populations. We downloaded SNP allele frequencies from the ALlele FREquency Database to observe the global genetic variation distribution for these specific loci. And then we used Structure software to perform the genetic structure analysis of 12 populations. CONCLUSIONS: Our results demonstrated that different polymorphic allele frequencies exist between different nationalities,and indicated Mongol is most similar to Chinese populations, followed by JPT. This information on the Mongol population complements the existing pharmacogenomic data and provides a theoretical basis for screening and therapy in the different ethnic groups within Xinjiang.
Agid:
5484686