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Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles

Ortiz de Solorzano Isabel, Prieto Martín, Mendoza Gracia, Alejo Teresa, Irusta Silvia, Sebastian Victor, Arruebo Manuel
ACS Applied Materials & Interfaces 2016 v.8 no.33 pp. 21545-21554
biodegradability, biodegradation, copper, nanoparticles, reactive oxygen species, sulfides
The continuous synthesis of biodegradable photothermal copper sulfide nanoparticles has been carried out with the aid of a microfluidic platform. A comparative physicochemical characterization of the resulting products from the microreactor and from a conventional batch reactor has been performed. The microreactor is able to operate in a continuous manner and with a 4-fold reduction in the synthesis times compared to that of the conventional batch reactor producing nanoparticles with the same physicochemical requirements. Biodegradation subproducts obtained under simulated physiological conditions have been identified, and a complete cytotoxicological analysis on different cell lines was performed. The photothermal effect of those nanomaterials has been demonstrated in vitro as well as their ability to generate reactive oxygen species.