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Persistent Luminescent Nanocarrier as an Accurate Tracker in Vivo for Near Infrared-Remote Selectively Triggered Photothermal Therapy

Author:
Zheng, Bin, Chen, Hong-bin, Zhao, Pei-qi, Pan, Hui-zhuo, Wu, Xiao-li, Gong, Xiao-qun, Wang, Han-jie, Chang, Jin
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.33 pp. 21603-21611
ISSN:
1944-8252
Subject:
cell death, irradiation, luminescence, nanocarriers, neoplasms, porous media, silica
Abstract:
Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode has caused strong tissue autofluorescence of the living tissue, which leads to the accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICG+PLPs)@mSiO₂) were first designed and prepared for persistent luminescent imaging-guided PTT. The (ICG+PLPs)@mSiO₂ nanocarriers could significantly improve signal-to-noise ratio during luminescence imaging-guided PTT, making the PLP promising for improving the accuracy of the tumor site for photothermal therapy in vivo. This paper is likely to develop a new way for accurately regulating cancer cell death based on luminescence imaging-guided PTT selectively triggered by near-infrared (NIR)-remote.
Agid:
5486855