PubAg

Main content area

Macrocyclic Metal Complex–DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

Author:
Duprey, Jean-Louis H. A., Carr-Smith, James, Horswell, Sarah L., Kowalski, Jarosław, Tucker, James H. R.
Source:
Journal of the American Chemical Society 2016 v.138 no.3 pp. 746-749
ISSN:
1520-5126
Subject:
DNA, copper, electrochemistry
Abstract:
The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.
Agid:
5487231