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Macrocyclic Metal Complex–DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA
- Duprey, Jean-Louis
H. A., Carr-Smith, James, Horswell, Sarah L., Kowalski, Jarosław, Tucker, James H. R.
- Journal of the American Chemical Society 2016 v.138 no.3 pp. 746-749
- DNA, copper, electrochemistry
- The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.