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Changes in the Composition of Adiponectin Fractions over a 3-Year Period in Children: A Population-Based Cohort Study

Nishimura, Rimei, Sano, Hironari, Shirasawa, Takako, Matsudaira, Toru, Miyashita, Yumi, Ochiai, Hirotaka, Kokaze, Akatsuki, Tajima, Naoko, Utsunomiya, Kazunori
Childhood obesity 2016 v.12 no.6 pp. 440-445
adiponectin, body mass index, boys, childhood obesity, children, cohort studies, girls, normal values, Japan
Background: Little information is available regarding changes in adiponectin fractions. The objective of this study was to examine changes in the composition of differing adiponectin fractions using a population-based, prospective pediatric cohort.Methods: A total of 358 fourth graders (9–10 years old) from Ina town in Saitama, Japan, were followed up for 3 years. BMI and total adiponectin (TAD), high–molecular weight adiponectin (HAD), medium–molecular weight adiponectin, and low–molecular weight adiponectin levels were measured in these subjects at baseline and at the end of the follow-up.Results: Of the fourth graders participating in the study, 326 (172 boys and 154 girls; follow-up rate, 91.1%) became available for follow-up. No significant changes were observed in TAD values after 3 years. HAD values were significantly decreased in both the boys (2.4 to 2.2 μg/mL: p < 0.001) and girls (3.1 to 2.7 μg/mL: p = 0.005). All values in the parameters examined at baseline and after 3 years were significantly correlated. A negative correlation was found between the ratios of follow-up compared to baseline values for BMI and those for TAD (boys, r = −0.322, p < 0.001; girls, r = −0.433, p < 0.001) as well as those for HAD (boys, r = −0.353, p < 0.001; girls, r = −0.351, p < 0.001).Conclusions: HAD had the most robust correlation between its values at baseline and those after 3 years in both boys and girls. The changes in HAD also had the most robust correlation between the changes in BMI in 3 years.