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Cytotoxic Iridoids from the Roots of Patrinia scabra

Author:
Li, Ning, Di, Lei, Gao, Wen-Chao, Wang, Kai-Jin, Zu, Ling-Bo
Source:
Journal of natural products 2012 v.75 no.10 pp. 1723-1728
ISSN:
1520-6025
Subject:
Patrinia, carcinoma, cytotoxicity, human cell lines, inhibitory concentration 50, iridoid glycosides, roots, uterine cervical neoplasms
Abstract:
Six new iridoid glucosides, patriridosides D–I (1–6), and one new iridoid, scabrol A (7), along with 12 known non-glycosidic and glycosidic iridoids (8–19), have been isolated from an ethanolic extract of the roots of Patrinia scabra. The cytotoxic activity of the isolated compounds against human cervical carcinoma HeLa cells and gastric carcinoma MNK-45 cells was evaluated using the MTT assay. Compounds 1, 4–6, 8, and 18 showed cytotoxic activities against the MNK-45 cell line with respective IC₅₀ values of 15.6, 8.7, 9.4, 30.9, 23.8, and 11.2 μM, while only compound 10 showed cytotoxicity against the HeLa cell line, with an IC₅₀ value of 24.5 μM.
Agid:
5493504