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PPARγ Agonist from Chromolaena odorata

Author:
Zhang, Man-Li, Irwin, Dianne, Li, Xiao-Ning, Sauriol, Françoise, Shi, Xiao-Wei, Wang, Yu-Fang, Huo, Chang-Hong, Li, Li-Geng, Gu, Yu-Cheng, Shi, Qing-Wen
Source:
Journal of natural products 2012 v.75 no.12 pp. 2076-2081
ISSN:
1520-6025
Subject:
Chromolaena odorata, agonists, median effective concentration, transcriptional activation, ursolic acid
Abstract:
A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known compounds, odoratin (6), 3β-acetyloleanolic acid (7), ursolic acid (8), ombuin (9), 4,2′-dihydroxy-4′,5′,6′-trimethoxychalcone (10), (−)-pinoresinol (11), austrocortinin (12), tianshic acid (13), cleomiscosin D (14), (−)-medioresinol (15), (−)-syringaresinol (16), and cleomiscosin A (17). All the compounds were evaluated for their PPARγ transactivation activity, and compound 6 showed moderate activity with an EC₅₀ value of 3.10 μM.
Agid:
5493549