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Antifouling Eunicellin-Type Diterpenoids from the Gorgonian Astrogorgia sp.

Author:
Lai, Daowan, Liu, Dong, Deng, Zhiwei, van Ofwegen, Leen, Proksch, Peter, Lin, Wenhan
Source:
Journal of natural products 2012 v.75 no.9 pp. 1595-1602
ISSN:
1520-6025
Subject:
Balanus amphitrite, antifouling activities, diterpenoids, larvae, median effective concentration, spectral analysis
Abstract:
Twelve new eunicellin-based diterpenoids, astrogorgins B–M (1–12), were isolated from a Chinese gorgonian Astrogorgia sp., together with ophirin, muricellin, astrogorgin, calicophirins A and B, and 14-deacetoxycalicophirin B. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant antifouling activity was observed for 14-deacetoxycalicophirin B against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations with an EC₅₀ = 0.59 μg/mL, while the other analogues were effective within an EC₅₀ range of 5.14–17.8 μg/mL.
Agid:
5493799