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(M)- and (P)-Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus
- Wang, Luo-Yi, Wu, Jian, Yang, Zhuo, Wang, Xu-Jie, Fu, Yan, Liu, Shuang-Zhu, Wang, Hong-Min, Zhu, Wei-Liang, Zhang, Hai-Yan, Zhao, Wei-Min
- Journal of natural products 2013 v.76 no.4 pp. 745-749
- Celastrus orbiculatus, X-ray diffraction, bark, cell viability, hydrogen peroxide, neuroprotective effect, spectroscopy
- (M)-Bicelaphanol A (1) and (P)-bicelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses. Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM.