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Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii

Author:
Zhan, Rui, Li, Xiao-Nian, Du, Xue, Wang, Wei-Guang, Dong, Ke, Su, Jia, Li, Yan, Pu, Jian-Xin, Sun, Han-Dong
Source:
Journal of natural products 2013 v.76 no.7 pp. 1267-1277
ISSN:
1520-6025
Subject:
X-ray diffraction, aerial parts, cytotoxicity, diterpenoids, humans, macrophages, nitric oxide, spectral analysis
Abstract:
Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B–P (2–16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1–16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
Agid:
5494061