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11β-HSD1 Inhibitors from Walsura cochinchinensis
- Han, Mei-Ling, Shen, Yu, Wang, Guo-Cai, Leng, Ying, Zhang, Hua, Yue, Jian-Min
- Journal of natural products 2013 v.76 no.7 pp. 1319-1327
- X-ray diffraction, inhibitory concentration 50, limonoids, mice, spectral analysis
- A search for inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) from Walsura cochinchinensis yielded 10 new limonoids, cochinchinoids A–J (1–10), and two new triterpenoids, 3-epimesendanin S (11) and cochinchinoid K (12). Their structures were assigned on the basis of spectroscopic data, with the absolute configurations of 1 and 12 being established by X-ray diffraction analysis. Of these compounds, cochinchinoid K (12) displayed inhibitory activity against mouse 11β-HSD1 with an IC₅₀ value of 0.82 μM.