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Antiplasmodial and Cytotoxic Flavans and Diarylpropanes from the Stems of Combretum griffithii

Author:
Moosophon, Panawan, Kanokmedhakul, Somdej, Kanokmedhakul, Kwanjai, Buayairaksa, Mongkol, Noichan, Jirawan, Poopasit, Kitisak
Source:
Journal of natural products 2013 v.76 no.7 pp. 1298-1302
ISSN:
1520-6025
Subject:
Combretum, antimalarials, antiparasitic properties, beta-sitosterol, breast neoplasms, carcinoma, cytotoxicity, ethyl acetate, flavonoids, humans, inhibitory concentration 50, lung neoplasms, stems
Abstract:
Four new flavans, griffinoids A–D (1–4), and two new diarylpropanes, griffithanes E and F (7 and 8), together with two known flavans (5 and 6), four known diarylpropanes, and β-sitosterol, were isolated from the EtOAc extract of the stems of Combretum griffithii. Compounds 3, 4, 5, and 9 exhibited weak antiplasmodial activity, with IC₅₀ values of 15.74, 13.04, 9.66, and 14.45 μM, respectively. In addition, compounds 4, 5, and 8 also exhibited weak cytotoxicity toward one or more cancer cell lines including human epidermoid carcinoma, human breast cancer, and human small cell lung cancer cell lines.
Agid:
5494069