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Pharbinilic Acid, an Allogibberic Acid from Morning Glory (Pharbitis nil)

Author:
Kim, Ki Hyun, Choi, Sang Un, Son, Mi Won, Choi, Sang Zin, Clardy, Jon, Lee, Kang Ro
Source:
Journal of natural products 2013 v.76 no.7 pp. 1376-1379
ISSN:
1520-6025
Subject:
Ipomoea nil, cytotoxicity, ethanol, neuroglia, nitric oxide, nuclear magnetic resonance spectroscopy, seeds
Abstract:
Pharbinilic acid (1), the first naturally occurring allogibberic acid, was isolated from ethanol extracts of morning glory (Pharbitis nil) seeds. Its absolute configuration was determined by NOESY NMR and ECD experiments. Compound 1 showed weak cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cells and weakly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglia cells.
Agid:
5494075