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Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa

Author:
Wu, Jiewei, Tang, Chunping, Yao, Sheng, Zhang, Lei, Ke, Changqiang, Feng, Linyin, Lin, Ge, Ye, Yang
Source:
Journal of natural products 2015 v.78 no.10 pp. 2332-2338
ISSN:
1520-6025
Subject:
Inula, anti-inflammatory activity, inhibitory concentration 50, lipopolysaccharides, macrophages, mass spectrometry, myo-inositol, nitric oxide, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Twelve new inositol derivatives, classified into myoinositol (1–6) and l-inositol (10–15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed anti-inflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC₅₀ values ranging from 7 to 23 μM.
Agid:
5494544