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Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Author:
Leutou, Alain S., Yang, Inho, Kang, Heonjoong, Seo, Eun Kyung, Nam, Sang-Jip, Fenical, William
Source:
Journal of natural products 2015 v.78 no.11 pp. 2846-2849
ISSN:
1520-6025
Subject:
Nocardiopsis, alkaloids, chemical structure, coasts, marine sediments, methylation, nuclear magnetic resonance spectroscopy, secondary metabolites, spectral analysis, California
Abstract:
Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.
Agid:
5494604