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Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi

Author:
Xie, Chunfeng, Sun, Lingmei, Liao, Kai, Liu, Sheng, Wang, Meicheng, Xu, Jing, Bartlam, Mark, Guo, Yuanqiang
Source:
Journal of natural products 2015 v.78 no.11 pp. 2800-2807
ISSN:
1520-6025
Subject:
Candida albicans, Chloranthus, X-ray diffraction, diterpenoids, inhibitory concentration 50
Abstract:
Two new ent-pimarane (1 and 2), eight new ent-abietane (3–10) diterpenoids, and eight known analogues (11–18) were isolated from the whole plants of Chloranthus henryi. The absolute configuration of 1 was determined on the basis of single-crystal X-ray diffraction data. Compound 8 represents a class of rare naturally occurring C-14 norabietanes, and compounds 9 and 10 feature rare 13,14-seco-abietane skeletons. Compounds 5, 12, 13, and 15 inhibited the yeast-to-hyphae transition of Candida albicans with IC₅₀ values between 97.3 and 738.7 μM.
Agid:
5494609