PubAg

Main content area

Meroterpenoids from a Tropical Dysidea sp. Sponge

Author:
Kim, Chang-Kwon, Woo, Jung-Kyun, Kim, Seong-Hwan, Cho, Eunji, Lee, Yeon-Ju, Lee, Hyi-Seung, Sim, Chung J., Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Source:
Journal of natural products 2015 v.78 no.11 pp. 2814-2821
ISSN:
1520-6025
Subject:
antimicrobial properties, chemical structure, cytotoxicity, hydroquinone, quinones, sesquiterpenoids, spectral analysis, Federated States of Micronesia
Abstract:
Six new meroterpenoids (1–6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4–6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na⁺/K⁺-ATPase.
Agid:
5494611