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Picrajavanicins A–G, Quassinoids from Picrasma javanica Collected in Myanmar

Author:
Win, Nwet Nwet, Ito, Takuya, Ismail,, Kodama, Takeshi, Win, Yi Yi, Tanaka, Masami, Ngwe, Hla, Asakawa, Yoshinori, Abe, Ikuro, Morita, Hiroyuki
Source:
Journal of natural products 2015 v.78 no.12 pp. 3024-3030
ISSN:
1520-6025
Subject:
Picrasma, anticarcinogenic activity, bark, chemical structure, humans, inhibitory concentration 50, neoplasm cells, neoplasms, nuclear magnetic resonance spectroscopy, Myanmar
Abstract:
Seven new tetracyclic quassinoids, picrajavanicins A–G (1–7), along with three known analogues, were isolated from a CHCl₃-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC₅₀ values >10 μM).
Agid:
5494634