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Puupehenol, a Potent Antioxidant Antimicrobial Meroterpenoid from a Hawaiian Deep-Water Dactylospongia sp. Sponge

Author:
Hagiwara, Kehau, Garcia Hernandez, Jaaziel E., Harper, Mary Kay, Carroll, Anthony, Motti, Cherie A., Awaya, Jonathan, Nguyen, Hoang-Yen, Wright, Anthony D.
Source:
Journal of natural products 2015 v.78 no.2 pp. 325-329
ISSN:
1520-6025
Subject:
antimicrobial properties, antioxidants, bioassays, nuclear magnetic resonance spectroscopy
Abstract:
From the organic extract of a deep-water Hawaiian sponge Dactylospongia sp., a new potent antioxidant and antimicrobial meroterpenoid, puupehenol (1), was isolated. The structure of 1 was determined using spectroscopic techniques (¹H and ¹³C NMR, MS, IR, UV, [α]D). The known compound puupehenone (2) was also isolated and suggested as a probable artifact of the isolation procedures. Complete unambiguous ¹H and ¹³C NMR data are provided for compounds 1 and 2. Bioassays performed with 1 and 2 showed them both to be very effective antioxidants and to have antimicrobial properties.
Agid:
5494655