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Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp.

Author:
Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje, Capon, Robert J.
Source:
Journal of natural products 2015 v.78 no.4 pp. 949-952
ISSN:
1520-6025
Subject:
Gram-negative bacteria, Gram-positive bacteria, Mycobacterium tuberculosis, Streptomyces, anthracyclines, antibiotics, chemical analysis, cytotoxicity, fungi, humans, inhibitory concentration 50, neoplasms, spectral analysis
Abstract:
Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1–4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC₅₀ >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC₅₀ >1.1 μM) and a panel of human cancer cell lines (IC₅₀ > 7.5 μM). Significantly, 1–4 were cytotoxic (IC₅₀ 0.7–1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin.
Agid:
5498132